A Clinical View of The Disease

The onset of diabetes mellitus is insidious, and the clinical course is often chronic. The dogs with Diabetes mellitus, clinically, exhibit polydipsia, polyuria, weight loss in spite of polyphagia, bilateral cataracts, and weakness.  The disturbances in water metabolism primarily are due to an osmotic basis. The persistent hyperglycemia and glycosuria cause an inability of the renal tubular epithelium to concentrate effectively the urine against the osmotic attraction of the glucose in the glomerular filtrate. The polydipsia (picture 1) is a mechanism found by the body in an attempt to compensate the water that is being lost in urine.

Picture 1. Polydipsia
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