Histopathology

Pancreas (pictures 1 and 2): Beta-cells are reduced in number (arrow 1) and remaining cells have a vacuolated cytoplasm (arrow 2). The islets are difficult to find when the disease is chronic.

Picture 1. Pancreas
Department of Veterinary Pathology - UFRGS

Picture 2. Pancreas
Department of Veterinary Pathology - UFRGS

Liver (picture 3): Individual hepatocytes are greatly enlarged by multiple droplets of lipid (arrow).

Picture 3. Liver
Department of Veterinary Pathology - UFRGS

Kidney (pictures 4 and 5): Renal lesions include accumulation of glycogen (arrow) within cells of the loop of Henle and distal convoluted tubule.

Picture 4. Kidney
Department of Veterinary Pathology - UFRGS

Picture 5. Kidney
Department of Veterinary Pathology - UFRGS